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Non-cryopreserved autologous peripheral blood stem cell transplantation for multiple myeloma and lymphoma in countries with limited resources: practice considerations from the Worldwide Network for Blood and Marrow Transplantation

Bekadja, Mohamed Amine
; 
Niederwieser, Dietger
; 
Kharfan-Dabaja, Mohamed A.
; 
El Fakih, Riad
; 
Garderet, Laurent
; 
Yakoub-Agha, Ibrahim
; 
Greinix, Hildegard
; 
Weisdorf, Daniel J.
; 
Galeano, Sebastian
; 
Ahmed, Syed Osman
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Author
Bekadja, Mohamed Amine
Niederwieser, Dietger
Kharfan-Dabaja, Mohamed A.
El Fakih, Riad
Garderet, Laurent
Yakoub-Agha, Ibrahim
Greinix, Hildegard
Weisdorf, Daniel J.
Galeano, Sebastian
Ahmed, Syed Osman
Chabanon, Christian
Hashmi, Shahrukh K.
Ruggeri, Annalisa
Gergis, Usama
Bazarbachi, Ali
Hamad, Nada
Albeihany, Amal
Pasquini, Marcelo
Hanbali, Amr
Szer, Jeff
Kodera, Yoshihisa
Kumar, Ambuj
Elhassan, Tusneem
McLornan, Donal
Worel, Nina
Greco, Raffaella
Mohty, Mohamad
Atsuta, Yoshiko
Koh, Mickey
Sureda, Anna
Rondelli, Damiano
Aljurf, Mahmoud
Rasheed, Walid
Supervisor
Department
Computer Vision
Embargo End Date
Type
Journal article
Date
2025
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Language
English
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Abstract
Autologous peripheral blood stem cell (PBSC) transplantation is a standard treatment of multiple myeloma (MM), Hodgkin lymphoma and various subtypes of non-Hodgkin lymphoma. Cryopreservation of hematopoietic stem cells is standard practice that allows time for delivery of conditioning regimen prior to cell infusion. The aim of this Worldwide Network for Blood & Marrow Transplantation (WBMT) work was to assess existing evidence on non-cryopreserved autologous transplants through a systematic review/meta-analysis, to study feasibility and safety of this approach. We searched PubMed, Web of Science and SCOPUS for studies that utilized non-cryopreserved autologous PBSC transplantation. Identified literature was reviewed for information on mobilization, apheresis, preservation and viability, conditioning regimen, engraftment, response, and survival. Results highlight collective experience from 19 transplant centers (1686 patients), that performed autologous transplants using non-cryopreserved PBSCs. The mean of infused CD34+ was 5.6?×?106/kg. Stem cell viability at transplantation was >90% in MM and >75% in lymphomas, after a storage time of 24–144?h at +4?°C. Mean time-to-neutrophil engraftment was 12 days and 15.3 days for platelets. Pooled proportion estimates of day 100 transplant-related mortality and graft failure were 1% and 0%, respectively. Non-cryopreservation of apheresed autologous PBSCs appears feasible and safe.
Citation
M. A. Bekadja et al., “Non-cryopreserved autologous peripheral blood stem cell transplantation for multiple myeloma and lymphoma in countries with limited resources: practice considerations from the Worldwide Network for Blood and Marrow Transplantation,” Bone Marrow Transplantation 2024 60:1, vol. 60, no. 1, pp. 19–27, Oct. 2024, doi: 10.1038/s41409-024-02431-y.
Source
Bone Marrow Transplantation
Conference
Keywords
Non-cryopreserved autologous peripheral blood stem cell transplantation, WBMT study, Hematopoietic stem cell transplantation, Cryopreservation alternatives, Transplantation outcomes
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Publisher
Springer Nature
DOI
10.1038/s41409-024-02431-y.
Additional links
https://www.nature.com/articles/s41409-024-02431-y
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