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International consensus statement on microbiome testing in clinical practice

Porcari, Serena
; 
Mullish, Benjamin H
; 
Asnicar, Francesco
; 
Ng, Siew C
; 
Zhao, Liping
; 
Hansen, Richard
; 
O'Toole, Paul W
; 
Raes, Jeroen
; 
Hold, Georgina
; 
Putignani, Lorenza
... show 10 more
Author
Porcari, Serena
Mullish, Benjamin H
Asnicar, Francesco
Ng, Siew C
Zhao, Liping
Hansen, Richard
O'Toole, Paul W
Raes, Jeroen
Hold, Georgina
Putignani, Lorenza
Hvas, Christian Lodberg
Zeller, Georg
Koren, Omry
Tun, Hein
Valles-Colomer, Mireia
Collado, Maria Carmen
Fischer, Monika
Allegretti, Jessica
Iqbal, Tariq
Chassaing, Benoit
Keller, Josbert
Baunwall, Simon Mark
Abreu, Maria
Barbara, Giovanni
Zhang, Faming
Ponziani, Francesca Romana
Costello, Sam P
Paramsothy, Sudarshan
Kao, Dina
Kelly, Colleen
Kupcinskas, Juozas
Youngster, Ilan
Franceschi, Francesco
Khanna, Sahil
Vehreschild, Maria
Link, Alexander
De Maio, Flavio
Pasolli, Edoardo
Blanco Miguez, Aitor
Brigidi, Patrizia
Posteraro, Brunella
Scaldaferri, Franco
Rajilic Stojanovic, Mirjana
Megraud, Francis
Malfertheiner, Peter
Masucci, Luca
Arumugam, Manimozhiyan
Kaakoush, Nadeem
Segal, Eran
Bajaj, Jasmohan
Leong, Rupert
Cryan, John
Weersma, Rinse K
Knight, Robert
Guarner, Francisco
Shanahan, Fergus
Cani, Patrice D
Elinav, Eran
Sanguinetti, Maurizio
de Vos, Willem M
El-Omar, Emad
Dore, Joel
Marchesi, Julian
Tilg, Herbert
Sokol, Harry
Segata, Nicola
Cammarota, Giovanni
Gasbarrini, Antonio
Ianiro, Gianluca
Supervisor
Department
Computational Biology
Embargo End Date
Type
Journal article
Date
2025
License
Language
English
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Abstract
There is growing interest in the potential exploitation of the gut microbiome as a diagnostic tool in medicine, but evidence supporting its clinical usefulness is scarce. An increasing number of commercial providers offer direct-to-consumer microbiome diagnostic tests without any consensus on their regulation or any proven value in clinical practice, which could result in considerable waste of individual and health-care resources and potential drawbacks in the clinical management of patients. We convened an international multidisciplinary expert panel to standardise best practices of microbiome testing for clinical implementation, including recommendations on general principles and minimum requirements for their provision, indications, pre-testing protocols, method of analyses, reporting of results, and potential clinical value. We also evaluated current knowledge gaps and future directions in this field. We aimed to establish a framework to regulate the provision of microbiome testing and minimise the use of inappropriate tests and pave the way for the evidence-based development and use of human microbiome diagnostics in clinical medicine.
Citation
S. Porcari et al., “International consensus statement on microbiome testing in clinical practice,” Lancet Gastroenterol Hepatol, vol. 10, no. 2, pp. 154–167, Feb. 2025, doi: 10.1016/S2468-1253(24)00311-X/ATTACHMENT/780C47E5-9825-4731-8A86-36B162899200/MMC1.PDF.
Source
The Lancet Gastroenterology & Hepatology
Conference
Keywords
Chronic hepatitis B, R, omized controlled trial, Novel treatment, Efficacy, Safety
Subjects
Source
Publisher
Elsevier
DOI
10.1016/S2468-1253(24)00311-X
Additional links
https://www.sciencedirect.com/science/article/abs/pii/S246812532400311X
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