Emerging frontiers in long-wavelength light-triggered nitric oxide release for therapeutic applications
Gan, Guihai Cheng, Jian Shen, Zhiqiang Yin, Dalong Hu, Jinming
Gan, Guihai
Cheng, Jian
Shen, Zhiqiang
Yin, Dalong
Hu, Jinming
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Department
Machine Learning
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Journal article
Date
2025
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English
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Abstract
Nitric oxide (NO) is a pivotal signaling molecule whose therapeutic potential is constrained by challenges in controlled delivery. Photocontrolled strategies employing red to near-infrared (NIR) light, known for deep tissue penetration and minimal phototoxicity, present transformative opportunities for spatiotemporally precise NO release. This review surveys emerging red/NIR-activated NO release platforms and elucidates core photochemical strategies, including direct red/NIR absorption by engineered NO donors, upconversion nanoparticles (UCNPs), two-photon excitation, and photoredox catalysis. These approaches demonstrate significant promise in a variety of applications, including targeted oncological therapies, antimicrobial interventions, and anti-inflammatory treatments, among others. A critical appraisal of prevailing challenges and future directions underscores the need for enhanced efficiency, biocompatibility, and multifunctional integration to facilitate clinical translation.
Citation
G. Gan, J. Cheng, Z. Shen, D. Yin, and J. Hu, “Emerging frontiers in long-wavelength light-triggered nitric oxide release for therapeutic applications,” Chemical Communications, vol. 61, no. 70, pp. 13080–13093, Aug. 2025, doi: 10.1039/D5CC03100A
Source
Chemical Communications
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Keywords
Nitric Oxide Delivery, Red/Near-Infrared Photocontrol, Upconversion Nanoparticles, Two-Photon Excitation, Photoredox Catalysis
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Publisher
Royal Society of Chemistry