Clinical translation of microbiome research
Gilbert, Jack A. Azad, Meghan B. Backhed, Fredrik Blaser, Martin J. Byndloss, Mariana Chiu, Charles Y. Chu, Hiutung Dugas, Lara R. Elinav, Eran Gibbons, Sean M.
Gilbert, Jack A.
Azad, Meghan B.
Backhed, Fredrik
Blaser, Martin J.
Byndloss, Mariana
Chiu, Charles Y.
Chu, Hiutung
Dugas, Lara R.
Elinav, Eran
Gibbons, Sean M.
Author
Gilbert, Jack A.
Azad, Meghan B.
Backhed, Fredrik
Blaser, Martin J.
Byndloss, Mariana
Chiu, Charles Y.
Chu, Hiutung
Dugas, Lara R.
Elinav, Eran
Gibbons, Sean M.
Gilbert, Katharine E.
Henn, Matthew R.
Ishaq, Suzanne L.
Ley, Ruth E.
Lynch, Susan V.
Segal, Eran
Spector, Tim D.
Strandwitz, Philip
Suez, Jotham
Tropini, Carolina
Whiteson, Katrine
Knight, Rob
Azad, Meghan B.
Backhed, Fredrik
Blaser, Martin J.
Byndloss, Mariana
Chiu, Charles Y.
Chu, Hiutung
Dugas, Lara R.
Elinav, Eran
Gibbons, Sean M.
Gilbert, Katharine E.
Henn, Matthew R.
Ishaq, Suzanne L.
Ley, Ruth E.
Lynch, Susan V.
Segal, Eran
Spector, Tim D.
Strandwitz, Philip
Suez, Jotham
Tropini, Carolina
Whiteson, Katrine
Knight, Rob
Supervisor
Department
Computational Biology
Embargo End Date
Type
Journal article
Date
2025
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Language
English
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Abstract
The landscape of clinical microbiome research has dramatically evolved over the past decade. By leveraging in vivo and in vitro experimentation, multiomic approaches and computational biology, we have uncovered mechanisms of action and microbial metrics of association and identified effective ways to modify the microbiome in many diseases and treatment modalities. This Review explores recent advances in the clinical application of microbiome research over the past 5 years, while acknowledging existing barriers and highlighting opportunities. We focus on the translation of microbiome research into clinical practice, spearheaded by Food and Drug Administration (FDA)-approved microbiome therapies for recurrent Clostridioides difficile infections and the emerging fields of microbiome-based diagnostics and therapeutics. We highlight key examples of studies demonstrating how microbiome mechanisms, metrics and modifiers can advance clinical practice. We also discuss forward-looking perspectives on key challenges and opportunities toward integrating microbiome data into routine clinical practice, precision medicine and personalized healthcare and nutrition.
Citation
J. A. Gilbert et al., “Clinical translation of microbiome research,” Nature Medicine 2025, pp. 1–15, Apr. 2025, doi: 10.1038/s41591-025-03615-9.
Source
Nature Medicine
Conference
Keywords
Microbiome, Cancer immunotherapy, Bioinformatic analysis, Tumor microenvironment, Host-microbe interactions
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Source
Publisher
Springer Nature